gramicidin s การใช้

This is in contrast to gramicidin S, which is a cyclic peptide chain.
It is synthesized by gramicidin S synthetase.
During his doctoral studies, Schmidt took part in structural studies of biologically important molecules, focusing on the structure of the antibacterial natural peptide Gramicidin S using the method of X-ray crystallography.
In three major studies, David Baker and co-workers " de novo " designed enzymes for the nonribosomal peptide synthetase that produces Gramicidin S, from its natural substrate phenylalanine to other noncognate substrates including charged amino acids; the redesigned enzymes had activities close to those of the wild-type.
By 1947, Martin, Synge and their collaborators had applied this method ( along with Fred Sanger's reagent for identifying N-terminal residues ) to determine the pentapeptide sequence of Gramicidin S . These and related paper chromatography methods were also foundational to Fred Sanger's effort to determine the amino acid sequence of insulin.